Fig. 6

miR-17-5p mimic attenuated infarction, downregulated TXNIP expression, NLRP3 inflammasome activation and IL-1β production at 24 h post HI. a, b Representative photographs of TTC-stained coronal brain sections (a) and quantitative analysis of infarct volume (b) at 24 h post HI. c–f Representative western blotting bands (c) and quantification (d–f) of TXNIP, cleaved caspase-1, and IL-1β expressions. g Representative Co-IP assay bands for interaction between NLRP3 and TXNIP. Data are expressed as mean ± SEM, n = 6 in each group. **P < 0.01 compared with sham group, *P < 0.05 compared with sham group, ^##P < 0.01 compared with HI group, ^#P < 0.05 compared with HI group, ^§§P < 0.01 compared with NC + HI group, and ^§P < 0.05 compared with NC+HI group. NC negative control