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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

Fig. 7

miR-17-5p inhibitor increased infarction, upregulated TXNIP expression, NLRP3 inflammasome activation and IL-1β production at 24 h post HI. a, b Representative photographs of TTC-stained coronal brain sections (a) and quantitative analysis of infarct volume (b) at 24 h post HI. cf Representative western blotting bands (c) and quantification (df) of TXNIP, cleaved caspase-1 and IL-1β expressions. g Representative Co-IP assay bands for interaction between NLRP3 and TXNIP. Data are expressed as mean ± SEM, n = 6 in each group. **P < 0.01 compared with sham group, *P < 0.05 compared with sham group, ##P < 0.01 compared with vehicle+HI group, #P < 0.05 compared with vehicle+HI group, §§P < 0.01 compared with STF+HI group, §P < 0.05 compared with STF+HI group, &&P < 0.01 compared with STF+NC+HI group, and &P < 0.05 compared with STF+NC+HI group

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