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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

Fig. 2

Elevated [18F]FSPG-PET signal in EAE mice at early stages of disease. a Disease scores of mice induced with EAE over 18 days. Arrows indicate PET/CT imaging time points and scores are represented as mean score ± SEM. b Representative sagittal PET/CT images of control, pre-symptomatic EAE (score 0), and EAE mice with early stage disease symptoms (score 1.5). Arrows indicate spinal cord uptake. Bl—bladder, Br—brain, H—Haderian glands, I—immunization site, K—kidneys, S—salivary glands. c Representative sagittal PET/CT images of identical brain sections of control, pre-symptomatic EAE (score 0), and symptomatic EAE (score 1.5) mice. Cb—cerebellum, HC—hippocampus, Mb—midbrain, Med—medulla. Dotted lines highlight region containing possible meningeal vessel(s). d Representative PET/CT volume rendering technique (VRT) image of EAE mouse (score 1.5). PET signal outside spinal column and skull was removed for better visualization of [18F]FSPG uptake in areas of interest

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