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Table 1 Uptake values (%ID/g) for different brain regions in pre-symptomatic and symptomatic mice and fold differences with respect to the same quantitation in control mice

From: [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

Brain regions 1 week post-immunization (pre-symptomatic mice) 2 weeks post-immunization (mice with clinical signs of EAE)
%ID/g in EAE mice Fold-differences EAE vs. controls %ID/g in EAE mice Fold-differences EAE vs. controls
Whole brain 0.38 ± 0.04 1.1 ± 0.1NS 0.48 ± 0.09 1.3 ± 0.2NS
Cerebellum 0.36 ± 0.06 1.1 ± 0.1NS 0.45 ± 0.10 1.6 ± 0.2**
Cortex 0.30 ± 0.04 1.1 ± 0.1NS 0.34 ± 0.08 1.2 ± 0.2NS
Hippocampus 0.32 ± 0.04 1.1 ± 0.1NS 0.38 ± 0.09 1.4 ± 0.2*
Hypothalamus 0.76 ± 0.13 1.2 ± 0.1* 0.97 ± 0.19 1.2 ± 0.2NS
Medulla 0.54 ± 0.08 1.1 ± 0.1NS 0.67 ± 0.17 1.5 ± 0.2*
Midbrain 0.29 ± 0.04 1.1 ± 0.1NS 0.35 ± 0.10 1.5 ± 0.2*
Olfactory bulb 0.64 ± 0.15 1.1 ± 0.1NS 0.97 ± 0.30 1.3 ± 0.3NS
Pallidum 0.45 ± 0.07 1.2 ± 0.1* 0.61 ± 0.13 1.2 ± 0.3NS
Pons 0.44 ± 0.07 1.0 ± 0.1NS 0.71 ± 0.25 1.3 ± 0.3NS
Striatum 0.34 ± 0.04 1.1 ± 0.1NS 0.42 ± 0.09 1.2 ± 0.2NS
Thalamus 0.28 ± 0.05 1.1 ± 0.1NS 0.32 ± 0.07 1.3 ± 0.2NS
  1. NS not significant
  2. Absolute [18F]FSPG uptake in brain regions as measured by PET, 75 min p.i. of radiotracer in EAE mice (n = 6–10, mean %ID/g ± SD) and fold differences ± SEM versus controls with indices indicating significance by Mann-Whitney test: **p = 0.001–0.01, *p = 0.01–0.05