Brain regions
|
1 week post-immunization (pre-symptomatic mice)
|
2 weeks post-immunization (mice with clinical signs of EAE)
|
---|
%ID/g in EAE mice
|
Fold-differences EAE vs. controls
|
%ID/g in EAE mice
|
Fold-differences EAE vs. controls
|
---|
Whole brain
|
0.38 ± 0.04
|
1.1 ± 0.1NS
|
0.48 ± 0.09
|
1.3 ± 0.2NS
|
Cerebellum
|
0.36 ± 0.06
|
1.1 ± 0.1NS
|
0.45 ± 0.10
|
1.6 ± 0.2**
|
Cortex
|
0.30 ± 0.04
|
1.1 ± 0.1NS
|
0.34 ± 0.08
|
1.2 ± 0.2NS
|
Hippocampus
|
0.32 ± 0.04
|
1.1 ± 0.1NS
|
0.38 ± 0.09
|
1.4 ± 0.2*
|
Hypothalamus
|
0.76 ± 0.13
|
1.2 ± 0.1*
|
0.97 ± 0.19
|
1.2 ± 0.2NS
|
Medulla
|
0.54 ± 0.08
|
1.1 ± 0.1NS
|
0.67 ± 0.17
|
1.5 ± 0.2*
|
Midbrain
|
0.29 ± 0.04
|
1.1 ± 0.1NS
|
0.35 ± 0.10
|
1.5 ± 0.2*
|
Olfactory bulb
|
0.64 ± 0.15
|
1.1 ± 0.1NS
|
0.97 ± 0.30
|
1.3 ± 0.3NS
|
Pallidum
|
0.45 ± 0.07
|
1.2 ± 0.1*
|
0.61 ± 0.13
|
1.2 ± 0.3NS
|
Pons
|
0.44 ± 0.07
|
1.0 ± 0.1NS
|
0.71 ± 0.25
|
1.3 ± 0.3NS
|
Striatum
|
0.34 ± 0.04
|
1.1 ± 0.1NS
|
0.42 ± 0.09
|
1.2 ± 0.2NS
|
Thalamus
|
0.28 ± 0.05
|
1.1 ± 0.1NS
|
0.32 ± 0.07
|
1.3 ± 0.2NS
|
- NS not significant
- Absolute [18F]FSPG uptake in brain regions as measured by PET, 75 min p.i. of radiotracer in EAE mice (n = 6–10, mean %ID/g ± SD) and fold differences ± SEM versus controls with indices indicating significance by Mann-Whitney test: **p = 0.001–0.01, *p = 0.01–0.05