[ 18 F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

Table 1 Uptake values (%ID/g) for different brain regions in pre-symptomatic and symptomatic mice and fold differences with respect to the same quantitation in control mice

Brain regions	1 week post-immunization (pre-symptomatic mice)		2 weeks post-immunization (mice with clinical signs of EAE)
Brain regions	%ID/g in EAE mice	Fold-differences EAE vs. controls	%ID/g in EAE mice	Fold-differences EAE vs. controls
Whole brain	0.38 ± 0.04	1.1 ± 0.1^NS	0.48 ± 0.09	1.3 ± 0.2^NS
Cerebellum	0.36 ± 0.06	1.1 ± 0.1^NS	0.45 ± 0.10	1.6 ± 0.2^**
Cortex	0.30 ± 0.04	1.1 ± 0.1^NS	0.34 ± 0.08	1.2 ± 0.2^NS
Hippocampus	0.32 ± 0.04	1.1 ± 0.1^NS	0.38 ± 0.09	1.4 ± 0.2^*
Hypothalamus	0.76 ± 0.13	1.2 ± 0.1^*	0.97 ± 0.19	1.2 ± 0.2^NS
Medulla	0.54 ± 0.08	1.1 ± 0.1^NS	0.67 ± 0.17	1.5 ± 0.2^*
Midbrain	0.29 ± 0.04	1.1 ± 0.1^NS	0.35 ± 0.10	1.5 ± 0.2^*
Olfactory bulb	0.64 ± 0.15	1.1 ± 0.1^NS	0.97 ± 0.30	1.3 ± 0.3^NS
Pallidum	0.45 ± 0.07	1.2 ± 0.1^*	0.61 ± 0.13	1.2 ± 0.3^NS
Pons	0.44 ± 0.07	1.0 ± 0.1^NS	0.71 ± 0.25	1.3 ± 0.3^NS
Striatum	0.34 ± 0.04	1.1 ± 0.1^NS	0.42 ± 0.09	1.2 ± 0.2^NS
Thalamus	0.28 ± 0.05	1.1 ± 0.1^NS	0.32 ± 0.07	1.3 ± 0.2^NS

NS not significant
Absolute [¹⁸F]FSPG uptake in brain regions as measured by PET, 75 min p.i. of radiotracer in EAE mice (n = 6–10, mean %ID/g ± SD) and fold differences ± SEM versus controls with indices indicating significance by Mann-Whitney test: **p = 0.001–0.01, *p = 0.01–0.05