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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

Fig. 5

Enhanced activation of IL-1 receptor, Src, and GluN2B-containing NMDA receptors leads to reduced phosphorylation of PKCζ at Thr560 in hyperammonemic rats. IL-1Ra, PP2, or ifenprodil were added to hippocampal slices. Phosphorylation of PKCζ at Thr560 was analyzed as described in the “Methods” section. Values are expressed as percentage of basal levels in control rats and are the mean ± SEM of 15 rats per group in a, b, and c. Data were analyzed by two-way ANOVA. In a, F (1, 55) = 1.077 for effect of HA, p = 0.3039; F (1, 55) = 1.220 for effect of IL-1Ra, p = 0.2742; and F (1, 55) = 14.93 for interaction, p = 0.0003. In b, F (1, 56) = 2.647 for effect of HA, p = 0.1093; F (1, 56) = 15.57 for effect of PP2, p = 0.0002; and F (1, 56) = 1.630 for interaction, p = 0.2069. In c, F (1, 55) = 10.21 for effect of HA, p = 0.0023; F (1, 55) = 30.59 for effect of ifenprodil, p < 0.0001; and F (1, 55) = 0.2520 for interaction, p = 0.6177. Values significantly different from control rats are indicated by asterisk and from hyperammonemic rats are indicated by “a”. Bonferroni post-test: *p < 0.05, ***p < 0.001, aap < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094