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Table 1 Secretions of inflammatory cytokines were measured by ELISA

From: Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

Cytokine Scratch Stretch LPS/ATP
Control VX-765 Casp-1−/− Control VX-765 Casp-1−/− Control VX-765 Casp-1−/−
IFN-γ (U/ml) 3.56 ± 0.46 3.03 ± 0.23* 3.16 ± 0.18* 3.72 ± 0.28 2.87 ± 0.14** 2.73 ± 0.26** 3.44 ± 0.16 2.31 ± 0.22** 2.27 ± 0.17**
IL-6 (ng/ml) 5.37 ± 0.41 3.01 ± 0.27*** 3.14 ± 0.35*** 4.67 ± 0.26 2.71 ± 0.18*** 2.63 ± 0.26*** 6.62 ± 0.47 3.64 ± 0.26*** 3.41 ± 0.37***
IL-1β (pg/ml) 483.26 ± 34.22 73.36 ± 5.16*** 53.43 ± 4.66*** 428.38 ± 56.71 63.17 ± 3.09*** 51.27 ± 4.57*** 803.52 ± 38.14 55.27 ± 3.56*** 43.71 ± 4.06***
IL-18 (pg/ml) 68.47 ± 4.46 11.63 ± 0.27*** 6.47 ± 0.38*** 77.73 ± 5.04 9.38 ± 0.17*** 7.36 ± 0.43*** 122.51 ± 4.18 8.67 ± 0.57*** 7.74 ± 0.39***
  1. Data are presented as the mean ± SEM
  2. *p < 0.05, **p < 0.01, and ***p < 0.001 versus control group, one representative experiment of five was shown