Table 1 Secretions of inflammatory cytokines were measured by ELISA
From: Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
Cytokine | Scratch | Stretch | LPS/ATP | ||||||
|---|---|---|---|---|---|---|---|---|---|
Control | VX-765 | Casp-1−/− | Control | VX-765 | Casp-1−/− | Control | VX-765 | Casp-1−/− | |
IFN-γ (U/ml) | 3.56 ± 0.46 | 3.03 ± 0.23* | 3.16 ± 0.18* | 3.72 ± 0.28 | 2.87 ± 0.14** | 2.73 ± 0.26** | 3.44 ± 0.16 | 2.31 ± 0.22** | 2.27 ± 0.17** |
IL-6 (ng/ml) | 5.37 ± 0.41 | 3.01 ± 0.27*** | 3.14 ± 0.35*** | 4.67 ± 0.26 | 2.71 ± 0.18*** | 2.63 ± 0.26*** | 6.62 ± 0.47 | 3.64 ± 0.26*** | 3.41 ± 0.37*** |
IL-1β (pg/ml) | 483.26 ± 34.22 | 73.36 ± 5.16*** | 53.43 ± 4.66*** | 428.38 ± 56.71 | 63.17 ± 3.09*** | 51.27 ± 4.57*** | 803.52 ± 38.14 | 55.27 ± 3.56*** | 43.71 ± 4.06*** |
IL-18 (pg/ml) | 68.47 ± 4.46 | 11.63 ± 0.27*** | 6.47 ± 0.38*** | 77.73 ± 5.04 | 9.38 ± 0.17*** | 7.36 ± 0.43*** | 122.51 ± 4.18 | 8.67 ± 0.57*** | 7.74 ± 0.39*** |