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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor

Fig. 6

Role of κ-opioid and neurokinin 1 receptors in GRe-mediated neuronal, astrocytic, and microglial modulation. Effects of neurokinin 1 receptor antagonist L-733,060 on κ-opioid receptor antagonist Nor-B-mediated pharmacological activity in response to effects of GRe against the changes in NeuN (a), GFAP (b), Iba-1 expression (c), and Iba-1-immunoreactivity (d) induced by MA in the striatum of DYN KO mice. Sal = saline, MA = methamphetamine 35 mg/kg, i.p., GRe = ginsenoside Re 20 mg/kg, i.p., Nor-B = Nor-binaltorphimine 3 or 6 mg/kg, i.p., L733 = L-733,060 5 or 10 mg/kg, i.p., GFAP = glial fibrillary acidic protein, Iba-1 = ionized calcium-binding adapter molecule 1, WT = wild type, DYN KO = prodynorphin knockout. Each value is the mean ± SEM of six animals (one-way ANOVA followed by Fisher’s LSD pairwise comparisons). Scale bar = 100 μm

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