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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury

Fig. 6

Perinatal HI brain injury shifts the peripheral T cell immune response towards pro-inflammatory. Mononuclear cells were isolated from the spleen of pups 7 days after HI injury and the phenotype of T helper cells was assessed by flow cytometry. a Proportion of CD4+ lymphocytes. b Proportion of CD4+IL4+ T cells. c Proportion of CD4+IFN-γ+ T cells. d Proportion of CD4+IL17+ T cells. e Ratio of Th1 cells (IFN-γ+) to Th2 cells (IL4+). f Ratio of Th17 cells (IL-17+) to Th2 cells (IL4+). g Concentration of IL4 protein produced by ionomycin and PMA stimulated spleen cells. h Proportion of regulatory T cells in the spleen. (n = 7–14 pups per group, *P < 0.05 compared to sham. ^^^P < 0.001, ^^P < 0.01, ^P < 0.05 compared to HI)

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