Fig. 6
From: Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice
Effect of Ang II on cerebral and systemic cytokine production. ELISA analysis of TNF-α and IL-6 in plasma (a, b) and whole brain homogenates (c, d) after 1 week perfusion of Ang II 200, 1000 ng/kg/min or 0.9% saline (CTL). LPS (2 mg/kg) was injected i.p. and mice were sacrificed 3 h after. A treated-to-control ratio was calculated. (*p < 0.05, **p < 0.01, ***p < 0.001 versus control, by one-way ANOVA with Tukey post-test, n = 6–8). e, f ELISA analysis in hippocampus (e) and plasma (f) of mice receiving Ang II 1000 ng/kg/min or 0.9% saline (CTL) for 1 week. Hydralazine (150 mg/L) was administered in the drinking water and started 3 days before minipump implantation. Animals in the vehicle group received regular drinking water. Results are expressed a treated-to-control ratio. (*p < 0.05 Ang II + vehicle versus control + vehicle, §p < 0.05 Ang II + Hyd versus Ang II + vehicle by two-way ANOVA with Tukey post-test, n = 6–9)