Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice

Table 1 Effect of Ang II doses on systolic blood pressure

Systolic blood pressure (SBP, mmHg) was assessed via the tail-cuff method. Mice were implanted with osmotic minipumps containing Ang II 200 ng/kg/min (referred as Ang II 200), Ang II 1000 ng/kg/min (referred as Ang II 1000), or 0.9% NaCl (referred as control). Data is expressed as mean ± SEM, n = 7–12/group; two-way ANOVA and Tukey post-test. Main effect of time F(2,92) = 5.203, p < 0.01; main effect of treatment F(2,92) = 12.95 p < 0.0001; interaction F(4,92) = 5.372, p < 0.001
^§p < 0.001 Ang II 1000 day 4 and day 7 versus day 0, ^¶p < 0.05 Ang II 1000 versus Ang II 200 and versus control, ⁺p < 0.001 Ang II 1000 versus Ang II 200 and versus control

ISSN: 1742-2094