| |
Control
|
Phenylephrine
|
Ang II 1900
|
|---|
|
SBP day 0
|
131.9 ± 3.2
|
132.3 ± 3.2
|
135.7 ± 1.0
|
|
SBP day 4
|
131.7 ± 2.2
|
142.5 ± 5.7*
|
158.5 ± 1.5§¶
|
|
SBP day 7
|
128.9 ± 0.5
|
145.6 ± 2.1*#
|
164.9 ± 2.3§+
|
- Systolic blood pressure (SBP, mmHg) was assessed via the tail-cuff method. Mice were implanted with osmotic minipumps containing phenylephrine 19 μg/kg/min, Ang II 1900 ng/kg/min (referred as Ang II 1900), or 0.9% NaCl (referred as control). Data is expressed as mean ± SEM, n = 3/group; two-way ANOVA and Tukey post-test. Main effect of time F(2,12) = 15.64, p = 0.0005; main effect of treatment F(2,6) = 73.5 p < 0.0001; interaction F(4,12) = 7.252, p = 0.003.3
- *p < 0.01 phenylephrine day 4 and day 7 versus control; #p < 0.05 phenylephrine day 7 versus day 0; §p < 0.001 Ang II 1900 day 4 and day 7 versus day 0; ¶p < 0.01 Ang II 1900 versus phenylephrine and versus control; +p < 0.001 Ang II 1900 versus phenylephrine and versus control
