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Table 3 Effect of hydralazine treatment on hypertension induced by Ang II

From: Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice

  Control Ang II Control + Hyd Ang II + Hyd
SBP day 0 127.0 ± 4.1 127.6 ± 2.5 119.4 ± 3.5 120.1 ± 3.6
SBP day 4 130.7 ± 3.7 165.4 ± 4.6§ 118.9 ± 3.5 131.0 ± 4.0
SBP day 7 125.4 ± 3.8 171.4 ± 5.3§ 115.2 ± 3.7 122.7 ± 2.6
  1. Systolic blood pressure (SBP, mmHg) was assessed via the tail-cuff method. Mice were implanted with osmotic minipumps containing Ang II 1000 ng/kg/min or 0.9% NaCl (referred as control). Hydralazine (Hyd, 150 mg/L) was administered in the drinking water and started 3 days before minipump implantation. Data is expressed as mean ± SEM, n = 11–20/group; two-way ANOVA with Tukey post-test. Main effect of time F(2,191) = 11.58, p < 0.0001; main effect of treatment F(3, 191) = 49.42, p < 0.0001; interaction F(6, 191) = 8.772, p < 0.0001
  2. §p < 0.0001 Ang II day 4 and day 7 versus day 0 and versus control; p < 0.0001 Ang II + Hyd versus Ang II on day 4 and day 7