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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Aging exacerbates development of cerebral microbleeds in a mouse model

Fig. 1

Surface and acute H&E-positive cerebral microhemorrhages (CMH). No development of surface CMH in young and aged saline-treated mice (n = 10 per group). Significant development of surface CMH in aged LPS-treated mice (n = 15) compared with young LPS-treated (n = 10) and aged saline-treated mice (n = 10) (a). No development of acute (H&E-positive) parenchymal CMH in saline-treated young mice. Significantly greater number, size, and total area of acute parenchymal CMH in LPS-treated aged mice compared with LPS-treated young mice and saline-treated aged mice (bd). Brain images showing development of surface CMH in LPS-treated aged mice compared with LPS-treated young mice (e). Representative images showing acute CMH in different brain regions (f). Data are presented as mean ± SEM. One-sample t test for surface CMH, one-way ANOVA with Bonferroni’s post-test, or Kruskal-Wallis test with Dunn’s post-test. *p < 0.05 and **p < 0.01. Scale bar = 100 μm

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