Fig. 3
From: Aging exacerbates development of cerebral microbleeds in a mouse model
Neuroinflammation, BBB disruption, and CMH development. Significantly higher Iba-1-positive immunoreactivity with aging (a), and GFAP- (b) and IgG- (c) positive immunoreactivity in LPS-treated aged mice compared with LPS-treated young mice. PB- and H&E-positive CMH numbers are significantly correlated with Iba-1 positive immunoreactivity in aged mice (d, e). Representative images of Iba-1, GFAP, and IgG immunohistochemistry (f). Data are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post-test or Kruskal-Wallis test with Dunn’s post-test and Pearson correlation; *p < 0.05, **p < 0.01, and ****p < 0.0001