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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury

Fig. 7

Nrg-1 therapy significantly attenuates antibody deposition in the injured spinal cord tissue at subacute stage of SCI. ad Immunohistochemical assessment of injured spinal cord tissue for IgM and IgG deposition was performed at the epicenter and perilesional areas at subacute (7 days) and chronic (42 days) stages of SCI. a, c Analysis of IgM immunointensity showed a significantly lower IgM deposition in Nrg-1-treated animals compared to vehicle-treated group at 7-day post-SCI. This decrease was significant at the epicenter, 1 mm caudal and 1 and 2 mm rostral to the injury site. No significant difference in IgM deposition was detected at 42-day time-point. b, d Comparison of IgG immunointensity between the vehicle- and Nrg-1-treated animals revealed a significant decrease in IgG deposition only at 1 mm rostral to the epicenter at 7-day post-injury. No significant difference was detected in IgG deposition between the vehicle- and Nrg-1-treated groups at 42-day time-point. e, f Representative images are provided at the epicenter and 1 mm rostral and caudal to the lesion center (N = 4/group/time-point, *p < 0.05, **p < 0.01, ***p < 0.001, two-way ANOVA followed by Holm-Sidak post hoc test)

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