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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis

Fig. 8

2-DG inhibited phagocytosis and NO production of macrophages in vitro. The phagocytosis of FITC-dextran was inhibited in the isolated peritoneal macrophages (a, b) and the LPS-activated RAW264.7 cells (4 mM 2-DG) (e, f), after 2-DG treatment, determined by flow cytometry. NO production in the LPS-stimulated peritoneal macrophages (c) and RAW264.7 cells (g) treated with different concentrations of 2-DG with or without glucose addition (glucose concentration increased 4 g/l, 8 g/l, respectively) were examined by Griess reagent. d TNF-α levels of the LPS-stimulated peritoneal macrophages were examined by ELISA. Results are expressed as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, one way ANOVA

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