Fig. 3

Effect of neurokinin-1 (NK1R) antagonism on LPS-induced anhedonia. Rats were treated with L822429 (30 mg/kg) 1 h prior to LPS (200 μg/kg) and sucrose consumption began 12 h after LPS injection. Systemic treatment with 200 μg/kg LPS decreases voluntary sucrose consumption in the two-bottle choice test. NK1R antagonism with systemic administration of 30 mg/kg L822429 attenuates LPS-induced decrease in sucrose preference. Data shown was collected 12 h post-LPS treatment. n = 6/group. **p < 0.01, compared to the vehicle-saline group, ^##p < 0.01 compared to the vehicle-LPS group