Fig. 7
RNS60 increases anti-oxidant response and reduces oxidative stress in the lumbar spinal cord of C57BL/6-SOD1G93A mice. Representative dot-blot (NT) or immunoblots (Nrf2) and relative quantification performed on the ventral portion of LSC of NTG mice or transgenic C57BL/6-SOD1G93A mice treated with NS or RNS60, at 20 weeks of age. a, b The levels of NT are increased in C57BL/6-SOD1G93A mice treated with NS compared to NTG mice, whereas they are similar to NTG in mice treated with RNS60. c, d While the levels of Nrf2 are reduced in C57BL/6-SOD1G93A mice treated with NS compared to NTG mice, the treatment with RNS60 prevented this reduction. Data are expressed as mean ± SEM, (n = 5 animals per group). All data were statistically analyzed using one-way ANOVA followed by post hoc Fisher’s LSD. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. = non significant