Table 1 Cohort demographics and HIV disease parameters

Number of subjects

112

350

92

–

Age at death, mean ± SD

54.5 ± 16.8

42.8 ± 10.1

41.1 ± 7.7

0.11^a

Hours postmortem, mean ± SD

15.2 ± 10.9

14.3 ± 13.3

15.5 ± 18.9

0.247^a

 Male (%)

67 (60%)

296 (85%)

85 (92%)

0.21^b

 Caucasian (%)

84 (76%)

209 (60%)

53 (58%)

0.88^b

 African American (%)

24 (22%)

116 (33%)

33 (36%)

 Other/Unknown (%)

3 (2.7%)

25 (7.1%)

6 (6.5%)

 Hispanic (%)

22 (20%)

65 (19%)

22 (24%)

0.25^b

 Log plasma HIV copies/mL, mean ± SD

4.1 ± 1.3

5.1 ± 0.9

< 0.001^a

 Log CSF HIV copies/mL, mean ± SD

2.8 ± 1.0

4.3 ± 1.6

< 0.001^a

 Log brain HIV copies/g, mean ± SD

3.6 ± 1.2

5.9 ± 1.9

< 0.001^a

 CD4+ lymphocytes/mm³, mean ± SD

–

111 ± 168

45 ± 58

0.003^a