Fig. 6

VCE-004.8 attenuates the clinical severity and neuropathology in EAE and TMEV models. a VCE-004.8 significantly ameliorated the clinical signs and progression of EAE. Results are expressed as mean ± SEM (n = 6 animals per group). **p < 0.01 ***p < 0.001 EAE + VEH vs CFA; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 EAE + VCE-004.8 vs EAE + VEH (one-way ANOVA followed Tukey’s test). The actimeter test showed a significant reduction of the horizontal exploratory activity (b) and of the vertical activity (c) of TMEV group at 78 dpi. The treatment with VCE-004.8 ameliorated the motor deficits in mice infected with Theiler’s virus. *p < 0.05 **p < 0.01 TMEV + VEH vs Sham; ^#p < 0.05, ^##p < 0.01 TMEV + VCE-004.8 vs TMEV + VEH (non-parametric Kruskal–Wallis test)