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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

Fig. 6

VCE-004.8 attenuates the clinical severity and neuropathology in EAE and TMEV models. a VCE-004.8 significantly ameliorated the clinical signs and progression of EAE. Results are expressed as mean ± SEM (n = 6 animals per group). **p < 0.01 ***p < 0.001 EAE + VEH vs CFA; #p < 0.05, ##p < 0.01, ###p < 0.001 EAE + VCE-004.8 vs EAE + VEH (one-way ANOVA followed Tukey’s test). The actimeter test showed a significant reduction of the horizontal exploratory activity (b) and of the vertical activity (c) of TMEV group at 78 dpi. The treatment with VCE-004.8 ameliorated the motor deficits in mice infected with Theiler’s virus. *p < 0.05 **p < 0.01 TMEV + VEH vs Sham; #p < 0.05, ##p < 0.01 TMEV + VCE-004.8 vs TMEV + VEH (non-parametric Kruskal–Wallis test)

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