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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

Fig. 8

VCE-004.8 significantly reduces microglial reactivity and infiltration of inflammatory cells and preserves myelin structure in TMEV-infected mice. Cross-sectional images of thoracic–lumbar spinal cord cross-sections of 30 μm thick, in which immunofluorescence with anti-Iba1 (a), anti-CD4 (b), H-E (c), cryomyelin (d), and neurofilament H staining (e) immunohistochemistry was performed. Treatment with VCE-004.8 reduces the number of CD4+ T cells, cell infiltrates (c, arrows), and a significant decrease in microglial reactivity (a). The quantifications are shown as means ± SEM, and significance was determined by Kruskal–Wallis non-parametric test. ***p < 0.001 vs Sham; ##p < 0.01, ###p < 0.001 vs TMEV + VEH. Scale bar: 150 μm (a), 100 μm (c and e). ***p < 0.001 unpaired two-tailed Student’s t test (d)

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