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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients

Fig. 4

Antigen-specific response in EAE is mediated by STAT protein phosphorylation. Splenocytes from EAE and control mice were stimulated with MOG35–55 peptide for 24 h and levels of p-p38MAPK, p-Erk1/2, p-STAT1, p-STAT3, p-STAT4, p-STAT5, and p-STAT6 were evaluated. Boxplots show the fold change in protein phosphorylation compared to unstimulated cells. MOG35–55 stimulation induced phosphorylation of STAT1 in all cell types, p38MAPK in B cells and CD4 T cells, STAT5 in CD4 and CD8 T cells, and STAT4 in CD4 T cells of EAE mice but not control mice. Statistical differences were calculated using an unpaired t test

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