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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Nitrosative damage during retrovirus infection-induced neuropathic pain

Fig. 1

Establishment of LP-BM5 infection-induced neuropathic pain and associated chronic immune activation. a WT animals were randomly assigned to LP-BM5-infected (Inf) and uninfected (UI) groups (n = 10/group). Hind-paw withdrawal threshold (in grams) was assessed on both left and right paws at various time points via MouseMet electronic Von Frey. *p < 0.05 between infected (Inf) and uninfected (UI) WT animals, and #p < 0.05 between infected (Inf) and uninfected (UI) WT animals (left and right paws, respectively). Data are presented as mean ± SEM paw withdrawal threshold. b Hind-paw withdrawal threshold (in grams) was assessed on both left and right paws at 10 weeks p.i. via MouseMet electronic Von Frey (n = 10/group). **p < 0.01 between infected (Inf) and uninfected (UI) WT animals. Data are presented as mean ± SEM paw withdrawal threshold. c LP-BM5 viral loads were determined by measuring the levels of BM5def (disease-inducing virus) and BM5eco (helper virus) gag RNA in the LSC (L3 to L5) and DRG (n = 12) during MAIDS at 10 weeks p.i. via real-time RT-PCR. Results are presented as box plots of pooled data from individual animals. d Chronic IFN-γ mRNA production was measured in LSC (L3 to L5) and DRG (n = 12) at 10 weeks p.i. via real-time RT-PCR. Results are presented as box plots of pooled data from individual animals

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