Fig. 1

Oligodendroglial cell death and proliferation rates upon stimulation with teriflunomide. a Application of high doses of teriflunomide for 1 day (1d) led to a substantial increase in the percentage of apoptotic OPCs cells as judged by the expression of activated caspase-3 (CC-3), whereas low concentration profiles (b, e–e”’) did not significantly change the naturally occurring death rate. Proliferation after 1d was significantly reduced upon high (c) and low (d, f–f”’) doses as indicated by the percentage of Ki-67-positive cells. Data are shown as mean; error bars represent SEM. Number of experiments: n = 2 for (a–d). t test (ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001). Scale bars, 30 μM