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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Fig. 3

The clinical course of MOG-induced EAE in C57BL/6J was attenuated, and the degeneration of the inner retinal layers was less pronounced in LA-treated mice. Prophylactic LA treatment acted beneficial on clinical EAE scores while later therapy had less pronounced effects (a). Thinning of the inner retinal layers was reduced during the EAE only when LA was administered prophylactically at the day of immunization or 7 days before while treatment at the onset of disease at day 14 had no effect (b). The correlation between the IRL thickness change and the EAE score at day 120 (c). GSH levels in the mouse cortices were significantly reduced after prophylactic LA treatment (d). Mice were scored daily, and OCT measurements were performed once a month over 120 days. GSH analysis was performed 120 days after EAE immunization. The time courses and bar graph present the pooled results of three independent EAE experiments with at least four mice per group (*p < 0.05; **p < 0.01; ***p < 0.001, area under the curve compared by ANOVA with Dunnett’s post hoc test for time courses. Associations were calculated with Spearman correlation; each point represents an eye, some data points overlap. ***p < 0.001; n.s. = not significant, by ANOVA with Dunnett’s post hoc test compared to MOG-untreated mice for bar graphs)

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