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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Fig. 4

Prophylactic LA treatment improved visual acuity of C57BL/6J mice compared to untreated mice with MOG EAE. OKR measurement was carried out 120 days after MOG immunization as described above (a). The bar graph represents the pooled mean ± standard deviation of at least three separate EAE experiments each with at least four animals per group (***p < 0.001, *p < 0.05, n.s. = not significant, by ANOVA with Dunnett’s post hoc test compared to MOG-untreated mice). We found a correlation between clinical EAE score and the spatial frequency threshold from OKR measurements at day 120 (b) as well as the OKR values and the thickness change of the inner retinal layers at day 120 (c). Associations were calculated with Spearman correlation; each point represents an eye, some data points overlap. Results represent data from three pooled experiments each with at least three mice per group

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Journal of Neuroinflammation

ISSN: 1742-2094