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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Fig. 5

In line with the results of the OCT measurements, LA treatment is beneficial for RGC survival in a MOG EAE in C57BL/6J. One hundred twenty days after immunization with MOG peptide, mice were sacrificed and an enucleation was performed followed by isolation and mounting of the retinae. RGCs were stained with βIII-tubulin antibody (a). The bar graph shows the RGC cell number 120 days after immunization; bar = 50 μm (b). The bar graph represents the pooled mean ± SEM of three separate EAE experiments each with at least four animals per group; one retina per mouse was included. (*p < 0.05; ***p < 0.001, by ANOVA with Dunnett’s post hoc test compared to MOG-untreated mice)

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Journal of Neuroinflammation

ISSN: 1742-2094