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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Fig. 7

Immune cell infiltration into the optic nerves was reduced after LA treatment. One hundred twenty days after MOG immunization, mice were sacrificed and optic nerves were extracted and processed and longitudinal cuts were prepared for HE staining, bar = 100 μm (a). Optic nerves from sham, MOG, and MOG with LA-treated mice were compared by an established infiltration score [41]; results are shown in the bar graph (b). The bar graph represents the pooled mean ± standard deviation of at least two separate EAE experiments each with at least four animals per group; one optic nerve per mouse was included (*p < 0.05, n.s. = not significant, by ANOVA with Dunnett’s post hoc test compared to MOG-untreated mice)

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Journal of Neuroinflammation

ISSN: 1742-2094