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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

Fig. 6

The effects of chronic intrathecal application of the suppressive anti-αβTCR antibodies on the development of mechanical allodynia after adult rat mSNIs. a Schematic illustration of lumbar catheterization and externalization with the self-made intrathecal bolus delivery system for repeated intrathecal injection. b1-b3, c1-c3, d1-d3 Representative images and quantitative presentations for the numbers of αβ T cells (b1-b3), CD4+ cells (c1–c3), and CD8+ cells (d1–d3) in the leptomeninges covering the proximal L4 DRs at the DR portions of the SAAs 24 h after acute intrathecal injection of mouse anti-αβTCR monoclonal antibodies or the corresponding isotype control IgGs at the beginning of the fifth day after mSNIs (n = 5/group). e Temporal dynamics of 50% PWTs (g) for both ipsilateral (ipsi) and contralateral (contra) hindpaws before and after mSNIs in animals with chronic intrathecal injection of mouse anti-αβTCR monoclonal antibodies or the corresponding isotype control IgGs (n = 5/group). *P < 0.05, **P < 0.01, ***P < 0.001; anti-αβTCR versus control IgG. mSNI modified spared nerve injury, PWT paw withdrawal threshold

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Journal of Neuroinflammation

ISSN: 1742-2094