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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

Fig. 7

The effects of prior lymphadenectomy to lumbar lymph nodes on mSNI-induced spinal sensitizations. a–d Representative images and quantitative presentations for temporal dynamics of astrocyte activation in the sural projection areas of L4 SC-DHs before and after mSNIs in lymphadenectomized or sham-operated animals to LLNs (n = 5/group). *P < 0.05; **P < 0.01; ***P < 0.001; lymphadenectomy versus sham operation. e–h Somatotopically PKCγ expression in PKCγ+ excitatory interneurons in the inner lamina II within the gray matter of L4 spinal cord dorsal horns before mSNIs and 7 days after mSNIs in lymphadenectomized or sham-operated animals to LLNs (n = 5/group). i MPI of PKCγ staining in the sural projection areas of L4 SC-DHs before mSNIs and 7 days after mSNIs in lymphadenectomized or sham-operated animals to LLNs (n = 5/group). ***P < 0.001; after versus before mSNIs. ###P < 0.001; lymphadenectomy versus sham operation. LLN lumbar lymph node, mSNI modified spared nerve injury, MPI mean pixel intensity

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Journal of Neuroinflammation

ISSN: 1742-2094