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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

Fig. 2

Lentivirus-mediated OTULIN overexpression exerted a neuroprotective role at 72 h after reperfusion in focal cerebral ischemia/reperfusion rats. a Schematic representation of the animal experiments over time. OTULIN mRNA (b, n = 5) and protein (c and d, n = 3) levels were elevated effectively by LV-OTULIN. The Longa score (e, n = 6), Bederson core (f, n = 6), and Garcia score (g, n = 6) were applied to assess neurological function deficits. i Quantification of infarction volumes was calculated based on TTC staining (h, n = 5). MAP2 (j, n = 6) and NeuN (j, n = 6) antibodies were used to stain neurons in the ischemic penumbra; scale bar = 75 μm. Quantification of the number of MAP2+/NeuN+ neurons was presented in panel k. All values are presented as the means ± SEMs; ###P < 0.001, ##P < 0.01, and #P < 0.05 versus the tMCAO group; &&&P < 0.001, &&P < 0.01, and &P < 0.05 versus the tMCAO+LV-Scramble group

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Journal of Neuroinflammation

ISSN: 1742-2094