Skip to main content
Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

Fig. 6

OTULIN overexpression reduced TNF-α, IL-1β, and IL-6 expression via the NF-κB signaling pathway at 24 h after reperfusion in tMCAO rats. The levels of TNF-α (a), IL-1β (b), and IL-6 (c) in the Sham, tMCAO, tMCAO+LV-Scramble, and tMCAO+LV-OTULIN groups were measured by ELISA (n = 6). e Quantitative analysis of the levels of p-IκBα and IκBα proteins in whole-cell preparations and p65 proteins in the cytoplasm and nucleus was detected by Western blot (d; n = 3). Data are presented as the means ± SEMs; ##P < 0.01, #P < 0.05 versus the tMCAO group; &&&P < 0.001, &&P < 0.01, &P < 0.05 versus the tMCAO+LV-Scramble group

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094