Fig. 6

The long-term effect of STZ-induced hyperglycemia on synaptogenesis on P90. Representative fluorescent photomicrographs of the hippocampal CA1 region immunostained for MAP2 (red) in a control and b hyperglycemia groups. Scale bars = 25 μm. Representative micrographs demonstrate qualitatively disorganized and truncated dendrites in the formerly hyperglycemic hippocampus compared with the hippocampus of the control rat. c The quantified average integrated density of fluorescent staining was decreased by 16% in the hyperglycemia group (gray) relative to the control group (black), *p < 0.05. d Protein expression of PSD95 in the hippocampus on P90 was decreased by 11% in the hyperglycemia group (gray) relative to the control group (black), *p < 0.05