Table 2 Relative mRNA expression of upstream and downstream effectors of CXCL10/CXCR3 signaling on P6
Transcript name | Gene ID | Description | Control group | STZ group |
|---|---|---|---|---|
PARP-1 (n = 6) | Parp1 | Poly(ADP-ribose) polymerase 1 | 1.0 ± 0.17 | 1.6 ± 0.13* |
NF-κB (n = 6) | Nfkb1 | Nuclear factor of κ light polypeptide gene enhancer in B cells 1 | 1.0 ± 0.10 | 2.8 ± 0.18* |
BCL2 (n = 12) | Bcl2 | B cell leukemia/lymphoma 2 | 1.0 ± 0.06 | 1.6 ± 0.07* |
AIF (n = 7) | Aifm1 | Apoptosis-inducing factor | 1.0 ± 0.10 | 1.1 ± 0.12 |
NR2B (n = 6) | Grin2b | Glutamate receptor, ionotropic, NMDA2B | 1.0 ± 0.10 | 0.6 ± 0.05* |