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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Therapeutic time window of multipotent adult progenitor therapy after traumatic brain injury

Fig. 2

Intravenous multipotent adult progenitor cell treatment at 2/24 and 6/24 h after traumatic brain injury improved spatial learning and memory as measured by the attenuation in latency to find the hidden platform. a Six-day spatial training paradigm in Morris water maze. b Six-day comparison of latency among groups indicating significant decreases in latency at 2/24 and 6/24 with comparison with CCI. (**p ≤ .01) Abbreviations: CCI, cortical contusion injury (untreated); 2/24, cortical contusion injury treated with MAPC 2/24 h after injury; 6/24, cortical contusion injury treated with MAPC 6/24 h after injury; 12/36, cortical contusion injury treated with MAPC 12/36 h after injury and 36/72 cortical contusion injury treated with MAPC 36/72 h after injury. c Duration in north quadrant increased significantly when MAPC was administered at 2/24 (*p ≤ .05) and 12/36 (***p ≤ .001) hours after injury. d Duration spent in platform proximity increased significantly when MAPC was administered at 2/24 (**p ≤ .01) and 6/24 (*p ≤ .05) hours after injury. Abbreviations: CCI, cortical contusion injury (untreated); 2/24, cortical contusion injury treated with MAPC 2/24 h after injury; 6/24, cortical contusion injury treated with MAPC 6/24 h after injury; 12/36, cortical contusion injury treated with MAPC 12/36 h after injury and 36/72 cortical contusion injury treated with MAPC 36/72 h after injury

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