Fig. 1

Late-phase MMP-9, but not TIMP-1, mRNA upregulation in the nerve post-CCI. Taqman qRT-PCR for MMP-9 (a) and TIMP-1 (b) in female rat sciatic nerve at day 0 (naïve) and days 1, 3, 5, 7, 14, 28, and 60 post-CCI. The mean relative mRNA ± SEM of n = 4/group was normalized to GAPDH, calibrated to the naïve nerve, and analyzed by one-way ANOVA and Tukey’s post hoc test (****p < 0.0001; ***p < 0.001; n.s., non-significant, compared to the naïve nerve). c The fold difference in the MMP-9 (black) and TIMP-1 (gray) mRNA levels at day 1 and day 28 post-CCI in (a, b). Expressed as a percentage relative to the respective value at day 1 (= 100%)