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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

Fig. 2

ILP/ISP treatment limits neutrophil infiltration but does not modulate MMP activity in acute SCI. a Myeloperoxidase (MPO) activity, a marker for neutrophils, was increased in the injured spinal cord at 1 day following SCI, which was attenuated by ILP/ISP treatment. b–d Matrix metalloproteinases (MMP)-2 and MMP-9 expression was also assessed using gel zymography. SCI-induced expression of MMP-2 and MMP-9 was observed at 1, 3, and 7 days post-SCI. However, there was no change in the levels of pro-MMP-9 (c) and pro-MMP-2 (d) under ILP/ISP treatment at any examined time-points. N = 4–6 animals/group/time-point. The data show mean ± SEM, *p < 0.05, one-way ANOVA (a–d)

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Journal of Neuroinflammation

ISSN: 1742-2094