Fig. 1
From: Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation
Involvement of LRP1 in Tat-mediated HIV-1 LTR transactivation. a The LRP1 antagonist, receptor-associated protein (RAP), concentration dependently reduced Tat-mediated HIV-1 LTR transactivation (n = 3; *p < 0.05). b Protein expression levels of LRP1 were significantly (n = 3, p < 0.05) reduced in U87MG cells transfected with LRP1 siRNA (100 nM) compared to cells transfected with control (scrambled) siRNA. c siRNA knockdown of LRP1 reduced significantly (n = 3; *p < 0.05) Tat-mediated HIV-1 LTR transactivation