Fig. 4
From: Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation
ApoE2 and ApoE3, but not ApoE4, inhibited HIV-1 Tat internalization. Representative images (a) and quantified internalized fluorescence intensities (b) show that ApoE2 and ApoE3 at 5 and 10 μg/ml inhibited HIV-1 Tat internalization as evidenced by lower levels of punctate staining of internalized FITC-labeled Tat (n = 30; ***p < 0.001, ****p < 0.0001), whereas ApoE4 did not inhibit HIV-1 Tat internalization