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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation

Fig. 5

ApoE mimetic peptide decreased Tat-mediated HIV-1 LTR transactivation. a U87MG cells were treated with an ApoE mimetic peptide in the presence of HIV-1 Tat and chloroquine (CQ) for 48 h. ApoE mimetic peptide significantly reduced Tat-mediated HIV-1 LTR transactivation (n = 3; *p < 0.05). b Incubation with an ApoE4 structure corrector, that makes the structure and function of ApoE4 more like ApoE3, enhanced the ability of ApoE4 to restrict Tat-mediated LTR transactivation (n = 3; *p < 0.05)

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