Fig. 1

TLR3 deficiency attenuates cocaine CPP, not sucrose CPP. a Experimental schedule for the cocaine-induced CPP tasks, cocaine injection (C), saline injection (S). b Cocaine produces significant CPP. **p < 0.01, n = 10/saline group, n = 13/cocaine groups (3, 10, 20 mg/kg). c TLR3 deficiency attenuates cocaine-induced CPP. *p < 0.05, **p < 0.01, n = 13/WT groups (3, 10, 20 mg/kg cocaine), n = 12/TLR3 KO groups (3, 10, 20 mg/kg cocaine). d Experimental schedule for the sucrose-induced CPP tasks. e Sucrose-induced CPP acquisition has no significant differences between TLR3KO and WT mice. n = 12/WT groups, n = 12/TLR3 KO groups. Data are presented as the mean ± SEM