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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats

Fig. 4

Overexpression of AZGP1 decreased the level of TGFβ and pERK in PTZ-kindled rats without affecting total ERK level. a, b Representative western blot bands of p-ERK and t-ERK in hippocampal tissues of rats. c Western blot showed GFP + PTZ group had significantly increased level of p-ERK and p-ERK/t-ERK ratio in hippocampal tissues compared to controls, and rats in AZGP1 + PTZ group had significantly decreased the level of pERK and pERK/tERK ratio compared to GFP + PTZ group. The level of tERK in hippocampal tissues is of no significant difference among the three groups. d Representative western blot bands of TGFβ in hippocampal tissues of rats. e Western blot showed increased level of TGFβ in the hippocampal tissues of rats in GFP + PTZ group compared to controls, and rats in AZGP1 + PTZ group had significantly decreased the level of TGFβ compared to GFP + PTZ group. Optic density was normalized by GAPDH, n = 5 for each group, *p < 0.05

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