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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

Fig. 3

Improvement of mechanical allodynia after PSL by systemic TC-2559. Mice were subject to PSL, and TC-2559 was administered (s.c., 2.28–22.8 μmol/kg) four times according to the indicated schedules. The 50% paw withdrawal mechanical threshold was assessed by the up–down method using the von Frey test. a Attenuation of PSL-induced mechanical allodynia in the ipsilateral side by TC-2559 (days 0, 1, 2, and 3) are shown. b There was no significant difference in the contralateral side in all groups. c Improvement of PSL-induced mechanical allodynia in the ipsilateral side by TC-2559 (days 7, 8, 9, and 10) are shown. Data are presented as the mean ± SEM; n = 5–9. ###P < 0.001, ##P < 0.01, #P < 0.05 versus PSL/Veh

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Journal of Neuroinflammation

ISSN: 1742-2094