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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

Fig. 7

Relieving effects of peripheral TC-2559 on upregulation of microglial molecules in the SDH after PSL. Mice were subject to PSL or sham surgery. TC-2559 was administered (p.n., 20 nmol) on days 7, 8, 9, and 10, and the lumbar SDH (L4–5) was collected. Expression levels of Iba1, CD11b, CD68, IRF5, IRF7, IL-1β, and CCL3 mRNA on day 14 after PSL were analyzed by RT-qPCR. Data are presented as the mean ± SEM; n = 4–8. **P < 0.01, *P < 0.05 versus sham. #P < 0.05 versus PSL/Veh

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Journal of Neuroinflammation

ISSN: 1742-2094