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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Fig. 5

In the presence of mAb158, Aβ is cleared from the cell culture media. Western blot analysis showed a reduction of Aβ in the cell culture media of cultures exposed to Aβ42 protofibrils + mAb158, compared to cultures exposed to Aβ42 protofibril only (a). The reduction was seen both in low-molecular Aβ at ~ 10 kDa (b) and ~ 5 kDa (c) and in the smear of Aβ detected at ~ 38–160 kDa (d). Intensity measurements were performed from three independent cell culture experiments, and statistical analysis was performed using one-way ANOVA followed by Tukey’s multiple comparison test (*P < 0.05)

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