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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome

Fig. 7

Langerhans cell (LC) numbers were increased in the affected skin of early CRPS patients. Fluorescent immunohistochemical staining of Langerin, an LC marker (red) in dorsal hand skin biopsies collected from the contralateral (a) and CRPS affected (b) sides. c Similar to the changes observed in the fracture mice, the number of epidermal LCs increased 40% in the CRPS-affected skin (IPSI), compared to the contralateral (CONTRA) side. Langerhans cells in CRPS-affected skin also exhibited exaggerated ramified processes suggesting cellular activation and differentiation. Dashed lines represent the epidermal-dermal border. Data were analyzed using paired Student’s t test, error bars indicate SEM, n = 8 per cohort. **P < 0.01 for vs. contralateral. Scale bar = 20 μm

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