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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells

Fig. 12

The effect of WP-sensitization on GFAP-immunoreactive perivascular astrocytes in the old male mouse brains. a Astrocytes were identified using GFAP-immunohistochemical staining in the brain sections (40 μm) of the old sham and WP-sensitized male mice. The striatum, thalamus, and substantia nigra are shown as low-power (left panels in each of the Sham and WP columns) and high-power (right panels) images. The arrows in the left panels indicate the areas where the high-power images were taken. Scale bar sizes are as indicated. Representative images are shown (n = 6). b Immunoreactivity to GFAP (GFAP-IR) within the young and old mouse brains was quantified by densitometric analyses of the digital photomicrographs taken with a ×4 objective. The values indicate group average optical density ± standard error (n = 5–6), *p < 0.005. Top graph, young mice; bottom graph, old mice

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