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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling

Fig. 8

NRG-1 inhibits STAT3 activation and ErbB4/AKT inactivation in vitro. hCMEC/D3 cells were treated with NRG-1 for 30 min followed by stimulation with 30 μM heme for 24 h. Lysates were extracted and stained with antibodies against STAT3, ErbB4, and AKT as indicated by Western blot. a NRG-1 inhibited heme-induced STAT3 activation, increased heme-reduced ErbB4/AKT activation. b A densitometric analysis of bands on blots was performed with the Image Quant program (Bio-Rad). The data are expressed as the fold stimulation relative to appropriate controls and are the mean ± SE of duplicated samples performed in three independent experiments. (*p < 0.05)

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