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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus

Fig. 4

Intra-amniotic exposure to LPS results in a decrease in mitotic cells and relatively late onset of cell death in the preterm white matter and hippocampus. A significant increase of caspase-3-positive cells is observed at 8 days following LPS exposure in the white matter compared to controls (SAL vs 8 days LPS p = 0.004) (a). In the hippocampus, at 2, 4, 8, and 15 days following LPS exposure an increase in caspase-3-positive cells was found compared to controls (SAL vs 2 days LPS p = 0.002; SAL vs 4 days LPS p = 0.030; SAL vs 8 days LPS p = 0.058; SAL vs 15 days LPS p = 0.042) (b). At 2 days following LPS exposure, a decrease in pHH3+ cells was found compared to controls (SAL vs. 2 days LPS p = 0.100) (c). Caspase-3 and pHH3 are expressed as positive cells/mm2 and represented in the graphs as mean ± 95% CI. Asterisk indicated p < 0.05 versus control (SAL); number sign indicated 0.05 < p < 0.1 versus control (SAL)

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