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Table 3 Uni- and multi-variate cox regression analysis of risk factors associated with relapse free survival

From: Platelet-derived growth factor predicts prolonged relapse-free period in multiple sclerosis

Univariable analysis

HR

95% CI

p value

Multivariable analysis

HR

95% CI

p value

Age, years

0.93

0.89–0.97

0.001

Age, years

0.93

0.89–0.97

0.002

Escalation to second line: no

1

Reference category

Escalation to second line: no

1

Reference category

Yes vs no

3.31

1.56–7.04

0.002

Yes vs no

2.7

1.18–6.18

0.018

PDGF groups: not detected PDGF

1

Reference category

PDGF category: not detected PDGF

1

Reference category

Medium PDGF vs not detected PDGF

0.5

0.20–1.21

0.124

Medium PDGF vs not detected PDGF

0.28

0.10–0.79

0.017

High PDGF vs not detected PDGF

0.36

0.14–0.92

0.033

PDGF vs not detected PDGF

0.33

0.13–0.89

0.029

MRI progression: no

1

Reference category

Not included in the multivariable final Cox regression model

Yes vs no

2.19

1.03–4.64

0.041

Sex: Male

1

Reference category

Female vs male

1

0.46–2.20

0.996

Disease duration, months

0.95

0.77–1.19

0.667

IL-12

0.99

0.99–1.00

0.137

GMCSF

1

0.99–1.01

0.908

FGF basic

0.99

0.95–1.03

0.555

GCSF

1.00

0.99–1.00

0.508

IL-10

0.99

0.98–1.01

0.328